Scoliosis: Life, Support & Friends

Genetic aspects of adolescent idiopathic scoliosis in a family with multiple affected members: a research article Authors: Marcelo Wajchenberg, Monize Lazar, Natale Cavaçana, Delio Eulalio Martins, Luciana Licinio, Eduardo Barros Puertas, Elcio Landim, Mayana Zatz and Akira Ishida Background The etiology of idiopathic scoliosis remains unknown and different factors have been suggested as causal. Hereditary factors can also determine the etiology of the disease; however, the pattern of inheritance remains unknown. Autosomal dominant, X-linked and multifactorial patterns of inheritances have been reported. Other studies have suggested possible chromosome regions related to the etiology of idiopathic scoliosis. We report the genetic aspects of and investigate chromosome regions for adolescent idiopathic scoliosis in a Brazilian family. Methods Evaluation of 57 family members, distributed over 4 generations of a Brazilian family, with 9 carriers of adolescent idiopathic scoliosis...

Abstract From the time of its initial, informal meetings starting in 1980 to its formal creation in 1990, the IRSSD has met on a bi-annual basis to discuss all aspects of the spine and associated deformities. It has encouraged open discussion on all topics and, in particular, has tried to be the seed-bed for new ideas. The members are spread around the world and include people from all areas of academia as well as the most important people, the patients themselves. Most notably, application of the ideas and results of the research has always been at the forefront of the discussions. This paper was conceived with the idea of evaluating the impact made by the IRSSD over the last 30 years in the various areas and is intended to create discussion for the upcoming meeting in Montreal regarding future focus: "We are lost over the Atlantic Ocean but we are making good time." Introduction Ever since the days when deformities of the spine were considered from a topographical poin...

Axial Biotech have entered into a partnership with the University of Utah to Utilise the Utah Population Database to Develop Personalised Diagnostic Tests for Spine Disorders. This could be great news for those with Scoliosis. Released on PRNEWSWIRE Date: 22nd July, 2009 Axial Biotech, Inc., a company personalizing spine care through the development of molecular diagnostics, and the University of Utah today announced that they have entered into a collaboration that allows Axial access to the University's rich genetic resources including the Utah Population Database (UPDB). UPDB is a genealogical and family history database composed of more than 6 million records that provides a rich source of information for genetic, epidemiological, demographic and public health studies which can be used to identify familial clusters of disease including spinal disorders. The UPDB combined with Axial's proprietary GenDB Genealogical Database will help Axial researchers expand the indications ...

Scoliosis Journal posted the following information regarding: Guidelines on "Standard of management of idiopathic scoliosis with corrective braces in everyday clinics and in clinical research": SOSORT Consensus 2008 Published: 16 January 2009 Authors: Stefano Negrini, Theodoros B Grivas, Tomasz Kotwicki, Manuel Rigo and Fabio Zaina Background Reported failure rates,(defined based on percentage of cases progressing to surgery) of corrective bracing for idiopathic scoliosis are highly variable. This may be due to the quality of the brace itself, but also of the patient care during treatment. The latter is sometimes neglected, even though it is considered a main determinant of good results among conservative experts of SOSORT. The aim of this paper was to develop and verify the Consensus on management of scoliosis patients treated with braces Methods We followed a Delphi process in four steps, distributing and gradually changing according to the results a set of recommendations...

MONTREAL, Nov. 18 /CNW Telbec/ - The CHU Sainte-Justine Research Center is proud to inaugurate its state-of-the art laboratory dedicated to the molecular genetics of musculoskeletal disorders. The laboratory with its global infrastructure is like no other in the world. Its aims will be twofold: to develop innovative diagnostic tools and therapeutic treatments to prevent and stop disease progression through tailored pharmacotherapies. Dr. Alain Moreau runs the Laboratory whose mission is to develop new molecular diagnostic tools for the early screening of scoliosis and other disorders that affect large numbers of children and adults and for which there are no tests. In addition, this state-of-the-art infrastructure will enable Dr. Moreau and his team to develop novel therapeutics aimed at preventing scoliosis or stopping its progression at an early stage. This represents a remarkable breakthrough leading to customized medicine that will revolutionize the treatment of scoliosis as well a...